The complex structure of Omicron BA.4 RBD with BD604, S309, and S304
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8hws
Q-score: 0.472
He Q, Wu L, Xu Z, Wang X, Xie Y, Chai Y, Zheng A, Zhou J, Qiao S, Huang M, Shang G, Zhao X, Feng Y, Qi J, Gao GF, Wang Q
Cell Rep Med (2023) 4 pp. 100991-100991 [ Pubmed: 37019110 DOI: doi:10.1016/j.xcrm.2023.100991 ]
- S309 fab heavy chain (25 kDa, Protein from Homo sapiens)
- S309 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.4/5 rbd in complex with fabs of bd-604, s304 and s309 (Complex from Homo sapiens)
- S304 fab light chain (23 kDa, Protein from Homo sapiens)
- S304 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bd-604 fab light chain (23 kDa, Protein from Homo sapiens)
- Bd-604 fab heavy chain (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron BA.2 RBD complexed with BD-604 and S304 Fab
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8hwt
Q-score: 0.448
He Q, Wu L, Xu Z, Wang X, Xie Y, Chai Y, Zheng A, Zhou J, Qiao S, Huang M, Shang G, Zhao X, Feng Y, Qi J, Gao GF, Wang Q
Cell Rep Med (2023) 4 pp. 100991-100991 [ Pubmed: 37019110 DOI: doi:10.1016/j.xcrm.2023.100991 ]
- Bd-604 light chain (23 kDa, Protein from Homo sapiens)
- S304 heavy chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron ba.2 rbd complexed with bd-604 and s304 fab (Complex from Homo sapiens)
- S304 light chain (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bd-604 heavy chain (24 kDa, Protein from Homo sapiens)
T1AM-bound mTAAR1-Gs protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jlj
Q-score: 0.543
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jlk
Q-score: 0.387
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
T1AM-bound hTAAR1-Gs protein complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8jln
Q-score: 0.427
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (43 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- T1am-bound htaar1 (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8jlo
Q-score: 0.473
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Htaar1-bound sep363856 in complex with gs heterotrimer (Complex)
- Sep-bound htaar1 (Complex from Homo sapiens)
Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jlp
Q-score: 0.433
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- 5-ethyl-4-methyl-~{n}-[4-[(2~{s})-morpholin-2-yl]phenyl]-1~{h}-pyrazole-3-carboxamide (314 Da, Ligand)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Ral-bound htaar1 (Complex from Homo sapiens)
- Htaar1-bound ral in complex with gs heterotrimer (Complex)
Fenoldopam-bound hTAAR1-Gs protein complex
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jlq
Q-score: 0.426
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- T1am-bound htaar1 (Complex from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
A77636-bound hTAAR1-Gs protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jlr
Q-score: 0.462
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- A7736-bound htaar1 (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound a77636 in complex with gs heterotrimer (Complex)
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- (1~{s},3~{r})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{h}-isochromene-5,6-diol (329 Da, Ligand)
AMPH-bound hTAAR1-Gs protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jso
Q-score: 0.439
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound amphetamine in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Amphetamine-bound htaar1 (Complex from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)